Analysis of Dermatologic Events in Vemurafenib-Treated Patients With Melanoma
Identifieur interne : 004843 ( Main/Exploration ); précédent : 004842; suivant : 004844Analysis of Dermatologic Events in Vemurafenib-Treated Patients With Melanoma
Auteurs : Mario E. Lacouture [États-Unis] ; Madeleine Duvic [États-Unis] ; Axel Hauschild [Allemagne] ; Victor G. Prieto [États-Unis] ; Caroline Robert [France] ; Dirk Schadendorf [Allemagne] ; Caroline C. Kim [États-Unis] ; Christopher J. Mccormack [Australie] ; Patricia L. Myskowski [États-Unis] ; Olivia Spleiss [Suisse] ; Kerstin Trunzer [Suisse] ; Fei Su [États-Unis] ; Betty Nelson [États-Unis] ; Keith B. Nolop [États-Unis] ; Joseph F. Grippo [États-Unis] ; Richard J. Lee [États-Unis] ; Matthew J. Klimek [États-Unis] ; James L. Troy [États-Unis] ; Andrew K. Joe [États-Unis]Source :
- The Oncologist [ 1083-7159 ] ; 2013.
Abstract
Vemurafenib has been approved for the treatment of patients with advanced BRAFV600E-mutant melanoma. The most commonly reported adverse events were dermatologic conditions, occurring in 92%–95% of patients. Dose interruptions and/or reductions were required in <10% of patients.
Url:
DOI: 10.1634/theoncologist.2012-0333
PubMed: 23457002
PubMed Central: 3607529
Affiliations:
- Allemagne, Australie, France, Suisse, États-Unis
- Californie, Massachusetts, New Jersey, Schleswig-Holstein, Texas, Wisconsin, État de New York
- Kiel
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Lacouture</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Duvic, Madeleine" sort="Duvic, Madeleine" uniqKey="Duvic M" first="Madeleine" last="Duvic">Madeleine Duvic</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hauschild, Axel" sort="Hauschild, Axel" uniqKey="Hauschild A" first="Axel" last="Hauschild">Axel Hauschild</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Prieto, Victor G" sort="Prieto, Victor G" uniqKey="Prieto V" first="Victor G." last="Prieto">Victor G. Prieto</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Dermatology, Cancer Institute Gustave Roussy, Villejuif, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Cancer Institute Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Dermatology, University Hospital Essen, Essen, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Caroline C" sort="Kim, Caroline C" uniqKey="Kim C" first="Caroline C." last="Kim">Caroline C. Kim</name><affiliation wicri:level="2"><nlm:aff id="aff7">Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mccormack, Christopher J" sort="Mccormack, Christopher J" uniqKey="Mccormack C" first="Christopher J." last="Mccormack">Christopher J. Mccormack</name><affiliation wicri:level="1"><nlm:aff id="aff8">Melanoma and Skin Service Team, Peter Macallum Cancer Institute, East Melbourne, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melanoma and Skin Service Team, Peter Macallum Cancer Institute, East Melbourne</wicri:regionArea><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Myskowski, Patricia L" sort="Myskowski, Patricia L" uniqKey="Myskowski P" first="Patricia L." last="Myskowski">Patricia L. Myskowski</name><affiliation wicri:level="2"><nlm:aff id="aff9">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Spleiss, Olivia" sort="Spleiss, Olivia" uniqKey="Spleiss O" first="Olivia" last="Spleiss">Olivia Spleiss</name><affiliation wicri:level="1"><nlm:aff id="aff10">Hoffmann-La Roche, Basel, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Hoffmann-La Roche, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Trunzer, Kerstin" sort="Trunzer, Kerstin" uniqKey="Trunzer K" first="Kerstin" last="Trunzer">Kerstin Trunzer</name><affiliation wicri:level="1"><nlm:aff id="aff10">Hoffmann-La Roche, Basel, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Hoffmann-La Roche, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Su, Fei" sort="Su, Fei" uniqKey="Su F" first="Fei" last="Su">Fei Su</name><affiliation wicri:level="2"><nlm:aff id="aff11">Hoffmann-La Roche, Nutley, New Jersey, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hoffmann-La Roche, Nutley, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Nelson, Betty" sort="Nelson, Betty" uniqKey="Nelson B" first="Betty" last="Nelson">Betty Nelson</name><affiliation wicri:level="2"><nlm:aff id="aff12">Genentech, San Francisco, California, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nolop, Keith B" sort="Nolop, Keith B" uniqKey="Nolop K" first="Keith B." last="Nolop">Keith B. Nolop</name><affiliation wicri:level="2"><nlm:aff id="aff13">Plexxikon, Berkeley, California, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Plexxikon, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Grippo, Joseph F" sort="Grippo, Joseph F" uniqKey="Grippo J" first="Joseph F." last="Grippo">Joseph F. Grippo</name><affiliation wicri:level="2"><nlm:aff id="aff11">Hoffmann-La Roche, Nutley, New Jersey, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hoffmann-La Roche, Nutley, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Lee, Richard J" sort="Lee, Richard J" uniqKey="Lee R" first="Richard J." last="Lee">Richard J. Lee</name><affiliation wicri:level="2"><nlm:aff id="aff11">Hoffmann-La Roche, Nutley, New Jersey, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hoffmann-La Roche, Nutley, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Klimek, Matthew J" sort="Klimek, Matthew J" uniqKey="Klimek M" first="Matthew J." last="Klimek">Matthew J. Klimek</name><affiliation wicri:level="2"><nlm:aff id="aff11">Hoffmann-La Roche, Nutley, New Jersey, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hoffmann-La Roche, Nutley, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Troy, James L" sort="Troy, James L" uniqKey="Troy J" first="James L." last="Troy">James L. Troy</name><affiliation wicri:level="2"><nlm:aff id="aff14">Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Joe, Andrew K" sort="Joe, Andrew K" uniqKey="Joe A" first="Andrew K." last="Joe">Andrew K. Joe</name><affiliation wicri:level="2"><nlm:aff id="aff11">Hoffmann-La Roche, Nutley, New Jersey, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hoffmann-La Roche, Nutley, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author></analytic><series><title level="j">The Oncologist</title><idno type="ISSN">1083-7159</idno><idno type="eISSN">1549-490X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Vemurafenib has been approved for the treatment of patients with advanced BRAF<sup>V600E</sup>-mutant melanoma. The most commonly reported adverse events were dermatologic conditions, occurring in 92%–95% of patients. Dose interruptions and/or reductions were required in <10% of patients.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Suisse</li><li>États-Unis</li></country><region><li>Californie</li><li>Massachusetts</li><li>New Jersey</li><li>Schleswig-Holstein</li><li>Texas</li><li>Wisconsin</li><li>État de New York</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Lacouture, Mario E" sort="Lacouture, Mario E" uniqKey="Lacouture M" first="Mario E." last="Lacouture">Mario E. Lacouture</name></region><name sortKey="Duvic, Madeleine" sort="Duvic, Madeleine" uniqKey="Duvic M" first="Madeleine" last="Duvic">Madeleine Duvic</name><name sortKey="Grippo, Joseph F" sort="Grippo, Joseph F" uniqKey="Grippo J" first="Joseph F." last="Grippo">Joseph F. Grippo</name><name sortKey="Joe, Andrew K" sort="Joe, Andrew K" uniqKey="Joe A" first="Andrew K." last="Joe">Andrew K. Joe</name><name sortKey="Kim, Caroline C" sort="Kim, Caroline C" uniqKey="Kim C" first="Caroline C." last="Kim">Caroline C. Kim</name><name sortKey="Klimek, Matthew J" sort="Klimek, Matthew J" uniqKey="Klimek M" first="Matthew J." last="Klimek">Matthew J. Klimek</name><name sortKey="Lee, Richard J" sort="Lee, Richard J" uniqKey="Lee R" first="Richard J." last="Lee">Richard J. Lee</name><name sortKey="Myskowski, Patricia L" sort="Myskowski, Patricia L" uniqKey="Myskowski P" first="Patricia L." last="Myskowski">Patricia L. Myskowski</name><name sortKey="Nelson, Betty" sort="Nelson, Betty" uniqKey="Nelson B" first="Betty" last="Nelson">Betty Nelson</name><name sortKey="Nolop, Keith B" sort="Nolop, Keith B" uniqKey="Nolop K" first="Keith B." last="Nolop">Keith B. Nolop</name><name sortKey="Prieto, Victor G" sort="Prieto, Victor G" uniqKey="Prieto V" first="Victor G." last="Prieto">Victor G. Prieto</name><name sortKey="Su, Fei" sort="Su, Fei" uniqKey="Su F" first="Fei" last="Su">Fei Su</name><name sortKey="Troy, James L" sort="Troy, James L" uniqKey="Troy J" first="James L." last="Troy">James L. Troy</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Hauschild, Axel" sort="Hauschild, Axel" uniqKey="Hauschild A" first="Axel" last="Hauschild">Axel Hauschild</name></region><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name></country><country name="France"><noRegion><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Mccormack, Christopher J" sort="Mccormack, Christopher J" uniqKey="Mccormack C" first="Christopher J." last="Mccormack">Christopher J. Mccormack</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Spleiss, Olivia" sort="Spleiss, Olivia" uniqKey="Spleiss O" first="Olivia" last="Spleiss">Olivia Spleiss</name></noRegion><name sortKey="Trunzer, Kerstin" sort="Trunzer, Kerstin" uniqKey="Trunzer K" first="Kerstin" last="Trunzer">Kerstin Trunzer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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